One of the most important concepts in modern biology is the fact that the complexity of life is encoded in the interaction of its units. Understanding and uncovering this network of interactions is a fundamental goal for systems biology and to our laboratory. We are interested in characterizing interactions at several scales: including amino acid or nucleotide interactions, physical interactions of functional domains, protein-protein, protein-rna/dna, macro molecular interactions, drug-molecule, gene and signaling networks as well as cellular interactions. Our focus has been traditionally to uncover hidden interactions but we are also dedicated to create predictive models and to study complexity in biological networks.
Faruck Morcos and Jose N. Onuchic The role of coevolutionary signatures in protein interaction dynamics, complex inference, molecular recognition, and mutational landscapes Current opinion in structural biology. 56, 179-186. 2019
Ricardo N dos Santos, Shahid Khan, Faruck Morcos. Characterization of C-ring component assembly in flagellar motors from amino acid coevolution. Royal Society Open Science.5 (5), 171854, 2018.
O. Karmi, S.H. Holt, L. Song, S. Tamir, Y. Luo, F. Bai, A. Adenwalla, M. Darash-Yahana, Y. Sohn, P.A. Jennings, R. K. Azad, J. N. Onuchic, F. Morcos, R. Nechushtai, R. Mittler Interactions between mitoNEET and NAF-1 in cells PLoS ONE. 12(4): e0175796. 2017
Joseph S. Boyd, Ryan R. Cheng, Mark L. Paddock, Cigdem Sancar, Faruck Morcos*, Susan S. Golden* A Combined Computational and Genetic Approach Uncovers Network Interactions of the Cyanobacterial Circadian Clock Journal of Bacteriology. 198:2439 –2447. 2016.
Ricardo N. dos Santos*, Faruck Morcos*, Biman Jana, Adriano D. Andricopulo and Jose N. Onuchic. Dimeric interactions and complex formation using direct coevolutionary couplings. Scientic Reports. 5:13652, 2015. (* equivalent contribution)
S. Tamir, M.L. Paddock, M. Darash-Yahana-Baram, S.H. Holt, Y.S. Sohn, L. Agranat, D. Michaeli, J.T. Sto-
eth, C.H. Lipper, Faruck Morcos, I.Z. Cabantchik, J.N. Onuchic, P.A. Jennings, R. Mittler, R. Nechushtai.
Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. Biochim. Biophys. Acta, 1853(6) 1294-1315, 2015
S. Tamir, S. Rotem, C. Katz , Faruck Morcos, K. Hailey, J. Zuris, C. Wang, A. Conlan, C. Lipper, M. Paddock, R. Mittler, J.N. Onuchic, P.A. Jennings, A. Frieddler, R. Nechushtai. An Integrated Strategy Reveals the Protein Interface between the Cancer Targets Bcl-2 and NAF-1. Proc Natl Acad Sci USA. 111(14) 5177-5182, 2014
Ryan Cheng, Faruck Morcos, Herbert Levine and Jose N. Onuchic. Towards rationally redesigning bacterial two-component signaling systems using coevolutionary information. Proc Natl Acad Sci USA . 111(5): E563-71, 2014
Press Highlight in Phys.org: Researchers tune in to protein pairs: Team quanties how mutations affect cell signaling in bacteria
Ramy Mourad, Zaher Dawy and Faruck Morcos. Designing Pooling Systems for Noisy High-Throughput Protein-Protein Interaction Experiments using Boolean Compressed Sensing. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 10(6): 1478-1490, 2013.
C. Harvey, Faruck Morcos, C. Sweet, D. Kaiser, S. Chatterjee, X. Liu, D. Chen and M. Alber. Study of elastic collisions of Myxococcus xanthus in swarms. Physical Biology. Vol. 8, No. 2, 2011.
Faruck Morcos, Marcin Sikora, Mark Alber, Dale Kaiser and Jesus A. Izaguirre. Belief Propagation Estimation of Protein and Domain Interactions using the Sum-Product Algorithm. IEEE Transactions on Information Theory. Vol. 56, No. 2, p. 742-755, 2010.
Faruck Morcos, Charles Lamanna, Marcin Sikora and Jesus Izaguirre. Cytoprophet: a Cytoscape plug-in for the protein and domain interaction networks inference. Bioinformatics , Vol. 24, Issue 19, pp. 2265-2266, 2008
Chengbang Huang, Faruck Morcos, Simon P. Kanaan, Stefan Wuchty, Danny Z. Chen, and Jesus A. Izaguirre. Predicting Protein-Protein Interactions from Protein Domains Using a Set Cover Approach. IEEE/ACM Transactions on Computational Biology and Bioinformatics , Vol. 4 pp. 78-87, 2007