One of the most important concepts in modern biology is the fact that the complexity of life is encoded in the interaction of its units. Understanding and uncovering this network of interactions is a fundamental goal for systems biology and to our laboratory. We are interested in characterizing interactions at several scales: including amino acid or nucleotide interactions, physical interactions of functional domains, protein-protein, protein-rna/dna, macro molecular interactions, drug-molecule, gene and signaling networks as well as cellular interactions. Our focus has been traditionally to uncover hidden interactions but we are also dedicated to create predictive models and to study complexity in biological networks.