{"id":295,"date":"2015-10-30T19:43:04","date_gmt":"2015-10-30T19:43:04","guid":{"rendered":"http:\/\/44.196.76.129\/?page_id=295"},"modified":"2025-07-14T20:28:16","modified_gmt":"2025-07-14T20:28:16","slug":"research-statistical-inference-2","status":"publish","type":"page","link":"https:\/\/morcoslaboratory.org\/?page_id=295","title":{"rendered":"Research – Statistical Inference & Machine Learning"},"content":{"rendered":"

\"Pdir\"<\/a>We are interested in developing new algorithms and tools to solve biological problems inspired by the abundance of biological information generated by current technologies. Our lab is interested in applying and developing new \u00a0principles of information theory, coding theory, statistical physics, statistical estimation and machine learning to understand biology from a data driven approach.\u00a0Another important objective of our lab is to create computational physical models of biomolecules and systems that can help us unravel fundamental biological phenomena\u00a0and produce testable hypothesis to\u00a0improve our understanding of molecular\u00a0processes and disease related mechanisms. Please find below some representative publications related to this area of interest in\u00a0our lab:<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Fernando Montalvillo Ortega, Fariha Hossain, Vladimir V Volobouev, Gabriele Meloni, Hedieh Torabifard, Faruck Morcos
\nGenerative Landscapes and Dynamics to Design Multidomain Artificial Transmembrane Transporters<\/span> ACS Central Science.<\/em> 2025. <\/p>\n<\/div><\/div><\/div><\/div>

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Priya M Christensen, Jonathan Martin, Aparna Uppuluri, Luke R Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli L PalmerLipid discovery enabled by sequence statistics and machine learning<\/span> Elife.<\/em> 13, RP94929, 2024.<\/p>\n<\/div><\/div><\/div><\/div>

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Jonathan Martin, Marcos Lequerica Mateos, Jos\u00e9 N Onuchic, Ivan Coluzza, Faruck Morcos. Machine learning in biological physics: From biomolecular prediction to design. <\/span> Proceedings of the National Academy of Sciences.<\/em> 121(27): e2311807121, 2024.<\/p>\n<\/div><\/div><\/div><\/div>

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Cheyenne Ziegler, Jonathan Martin, Claude Sinner, Faruck Morcos. Latent generative landscapes as maps of functional diversity in protein sequence space. <\/span> Nature Communications.<\/em> 14(1): 2222, 2023.<\/p>\n<\/div><\/div><\/div><\/div>

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Krithika Ravishankar, Xianli Jiang, Emmett M Leddin, Faruck Morcos, G Andr\u00e9s Cisneros. Computational compensatory mutation discovery approach: Predicting a PARP1 variant rescue mutation. <\/span> Biophysical Journal.<\/em> 121(19): 3663-3673, 2022.<\/p>\n<\/div><\/div><\/div><\/div>

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Jeffrey K. Noel, Faruck Morcos and Jose N. Onuchic. Sequence co-evolutionary information is a natural partner to minimally-frustrated models of biomolecular dynamics<\/span> F1000Research<\/em> 5(F1000 Faculty Rev):106. 5:13652, 2016.<\/p>\n<\/div><\/div><\/div><\/div>

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Ryan Cheng, Faruck Morcos, Herbert Levine and Jos\u0013e N. Onuchic. Towards rationally redesigning bacterial\u00a0two-component signaling systems using coevolutionary information. <\/span> Proc Natl Acad Sci USA <\/em>. 111(5): E563-71,\u00a02014
Press Highlight in Phys.org: Researchers tune in to protein pairs: Team quanti\fes how mutations a\u000bffect cell signaling in bacteria<\/a><\/p>\n<\/div><\/div><\/div><\/div>

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Faruck Morcos, Biman Jana, Terence Hwa and Jos\u0013e N. Onuchic. Coevolutionary signals across protein lineages help capture multiple protein conformations.<\/span> Proc Natl Acad Sci USA.<\/em> Vol 110, No. 51, p. 20533-20538. 2013
Press Highlight in ScienceDaily: Proteins' passing phases revealed<\/a><\/p>\n<\/div><\/div><\/div><\/div>

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Ramy Mourad, Zaher Dawy and Faruck Morcos. Designing Pooling Systems for Noisy High-Throughput Protein-Protein Interaction Experiments using Boolean Compressed Sensing. <\/span> IEEE\/ACM Transactions on Computational Biology and Bioinformatics.<\/em> 10(6): 1478-1490, 2013.<\/p>\n<\/div><\/div><\/div><\/div>

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Joanna I. Sulkowska*, Faruck Morcos*, Martin Weigt, Terence Hwa and Jose N. Onuchic. Genomics-aided structure prediction.<\/span> Proc Natl Acad Sci USA.<\/em> Vol. 109, No. 26, p. 10340-45, 2012. (*equivalent contribution)
\nProtein residues kiss, don't tell: Genomes reveal contacts, scientists refine methods for protein-folding prediction<\/a><\/p>\n<\/div><\/div><\/div><\/div>

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Faruck Morcos*, Andrea Pagnani*, Bryan Lunt, Arianna Bertolino, Debora S. Marks, Chris Sander, Riccardo Zecchina,
\nJose N. Onuchic, Terence Hwa and Martin Weigt. Direct-coupling analysis of residue coevolution captures native contacts across many protein families.<\/span> Proc Nat Acad Sci USA.<\/em> Vol. 108, No. 49, E1293-E1301, 2011. (*equivalent contribution) <\/p>\n<\/div><\/div><\/div><\/div>

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Faruck Morcos, Marcin Sikora, Mark Alber, Dale Kaiser and Jesus A. Izaguirre. Belief Propagation Estimation of Protein and Domain Interactions using the Sum-Product Algorithm.<\/span> IEEE Transactions on Information Theory.<\/em> Vol. 56, No. 2, p. 742-755, 2010.<\/p>\n<\/div><\/div><\/div><\/div>

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<\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

We are interested in developing new algorithms and tools to solve biological problems inspired by the abundance of biological information generated by current technologies. Our lab is interested in applying and developing new \u00a0principles of information theory, coding theory, statistical physics, statistical estimation and machine learning to understand biology from a data driven approach.\u00a0Another important Read More …<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":38,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-295","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/pages\/295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=295"}],"version-history":[{"count":37,"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/pages\/295\/revisions"}],"predecessor-version":[{"id":1770,"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/pages\/295\/revisions\/1770"}],"up":[{"embeddable":true,"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=\/wp\/v2\/pages\/38"}],"wp:attachment":[{"href":"https:\/\/morcoslaboratory.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}